GAP Peptide Synthesis (GAP-PS) embraces principles of Green Chemistry by focusing on waste prevention and energy efficiency; using safer solvents; and minimizing potential for accidents and hazardous conditions. The synthetic efficiency of the process significantly reduces raw materials and solvent consumed. Accordingly, a substantial reduction in hazardous waste is achieved compared to traditional SPPS processes. GAP-PS champions environmentally-friendly chemistry, including usage of 2-MeTHF as a solvent and CPME for precipitation following TFA deprotection. Research demonstrates the atom economy inherent in the method enables highly efficient reactions in minimal solvent volumes, dramatically reducing solvent and material waste by up to 80%.
Due to reaction efficiency, impurities are minimal and crude purity of the desired peptide is high. This reaction efficiency yields more product per reaction volume and reduces purification processing and waste materials – resulting in lower processing costs.
The GAP-PS approach creates significant economic advantages due to reduced consumption of raw material and reduced purification costs. The process avoids CMR substances and supports sustainability by reducing the usage and waste of hazardous chemicals, even enabling recycling of reaction solvent in some cases.