Publications & References

An Overview of Modern, Sustainably Designed LPPS Strategies
Authors: Seifert, C.W.; Brooks, C.S.; Brousseau R. Chemistry Today, 2021, 6, 57.

Applying GAP-PS: Green Manufacturing for Generic Drugs
Author: GAP Peptides, LLC

Alternative Strategies for Improving Sustainability and “Greening” Peptide Manufacturing
Author: Ambiopharm, Inc.
AmbioPharm, Inc gives a nod of approval to GAP Peptides’ efficient, economical, green synthesis approach and its commercial potential.

New Technology Developments in the Peptide Manufacturing World
Author: Ambiopharm, Inc.

Large Scale Peptide Synthesis Using GAP-PS
Authors: Seifert, C.W.; Brooks, C.S.

Driving Efficiency and Green Chemistry in Peptide Synthesis
Authors: Seifert, C.W.; Brooks, C.S.

Cost-Savings Potential of GAP-Peptide Synthesis 
Authors: Seifert, C.W.; Brooks, C.S.

Transforming Peptide Synthesis for the 21st Century: Group Assisted Purification Peptide Synthesis Phase 1 Feasibility Results
Authors: Seifert, C. W.; Brooks, C.W.; Brooks, C. S. 2019.

GAP Peptide Synthesis through the Design of a GAP Protecting Group: An Fmoc/tBu Synthesis of Thymopentin Free from Polymers, Chromatography, and Recrystallization
Authors: Seifert, C.W.; Paniagua, A.; White, G.A.; Cai,L.; Li,G. Eur. J. Org. Chem. 2016,  (9), 1714-1719.

Asymmetric Synthesis of Chiral alpha-Methyl-alpha, beta-diamino Acid Derivatives via Group-Assisted Purification Chemsitry Using N-Phosphonyl Imines and a Ni(II)-Complexed Alanine Schiff Base
Authors:  Zhang, H.W.; Yang, B.; Yang, Z.; Lu, H.J.; Li, G.G.  J. Org. Chem. 2016, 81 (17), 7654-7661.

Asymmetric Carbamoyl Anion Additions to Chiral N-Phosphonyl Imines via the GAP Chemistry Process and Stereoselectivity Enrichments
Authors:  Cole W. Seifert, Suresh Pindi, and Guigen Li.  J. Org. Chem. 2015, 80 (1), 447-452.

N-Phosphonyl/Phosphinyl Imines and Group Assisted Purification (GAP) Chemistry/Technology
Authors:  An, G.; Seifert,C.; Li, G. Org. Biomol. Chem. 2015, 13 (5), 1600-1617.

Solution-phase-peptide synthesis via group-assisted purification (GAP) chemistry without using chromatography and recrystallization 
Authors: Wu, J.; An, G.; Lin, S.; Xie, J.; Zhou, W.; Sun, H.; Pan, Y.; Li, G. Chem. Commun. 2014, 50, 1259-1261.

Design, synthesis, and applications of new chiral N-2-pheynl-2-propyl sulfinylimines for Group-Assisted Purification (GAP) asymmetric synthesis
Authors: Pindi, S.; Wu, J.; Li, G. J. Org. Chem. 2013, 78, 4006-4012.

N-Phosphinyl Imine Chemistry (I): Design and Synthesis of Novel N-Phosphyinyl Imines and their Application to Asymmetric aza-Henry Reaction
Authors: Pindi, S.; Kaur, P.; Shakya, G.; Li, G. Chemical Biology & Drug Design. 2011, 77 (1), 20-29.

Asymmetric Synthesis of α-Amino-1,3-dithianes via Chiral N-Phosphonyl Imine-Based Umpolung Reaction Without Using Chromatography and Recrystallization
Authors: Kattamuri, P.V; Ai, T.; Pindi, S.; Sun, Y.; Gu, P.; Shi, M.; Li, G. J. Org. Chem. 2011, 76 (8), 2792-2797.

The GAP chemistry for chiral N-phosphonyl imine-based Strecker reaction
Authors: Kaur, P.; Wever, W.; Pindi, S.; Milles, R.; Gu, P.; Shi, M.; Li, G.  Green Chem. 2011, 13 (5), 1288-1292.

Chiral N-phosphonyl imine chemistry; asymmetric additions of ester enolates for the synthesis of β-amino acids.
Authors:  Han, J.; Ai, T.; Nguyen, T.; Li, G. Chem. Biol. Drug Des. 2008, 72 (2), 120-126.